癫痫与热性惊厥患儿血清催乳素及一氧化氮/一氧化氮合酶测定的临床意义

目的探讨血清催乳素（PRL）、一氧化氮／一氧化氮合酶（NO／NOS）体系用于癫痫与热性惊厥的诊断和鉴别诊断的意义。方法分别采用化学发光法和分光光度法测定25例癫痫患儿、20例热性惊厥患儿及15例正常儿的血清PRL和NO／NOS水平。结果癫痫组血清PRL水平显著高于热性惊厥组和对照组（P〈0．05），癫痫组与热性惊厥组血清NO／NOS水平均显著高于对照组（P〈0．05），癫痫组显著高于热性惊厥组（P〈0．05）。结论检测癫痫与热性惊厥患儿血清中PRL、NO／NOS水平，可为临床诊断和鉴别诊断提供依据。

Detection of prolactin, nitric oxide and nitric oxide synthase in serum of children with epilepsy or febrile convulsions and its significance

Objective To study the role of prolactin and nitric oxide/nitric oxide synthase(NO/NOS) in diagnosis and differential diagnosis of childhood epilepsy and febrile convulsion.Methods The levels of prolactin and NO/NOS in the serum of 25 children with epilepsy,20 febrile convulsion,and 15 normal controls were detected by chemoluminescence technique and absorption spectrometry.Results The level of serum prolactin was significantly higher in epilepsy group than febrile convulsion and control groups(P < 0.05),but there was no significant difference between febrile convulsion group and control group(P > 0.05).The level of NO/NOS was significantly higher in epilepsy group and febrile convulsion group than control group(P < 0.05);moreover,the level in epilepsy group was higher than that in febrile convulsion group(P < 0.05).Conclusion Detecting the levels of serum prolactin and NO/NOS in children with epilepsy and febrile convulsion will be beneficial to the clinical diagnosis and differential diagnosis.