Influence of guar on serum lipids in patients with hyperlipidaemia |
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Authors: | R. Kirsten B. Domning K. Nelson K. Nemeth G. Oremek U. Hübner-Steiner U. Speck |
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Affiliation: | (1) Clinical Pharmacology and Central Laboratory, University of Frankfurt, Frankfurt, Germany |
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Abstract: | Summary The antihyperlipidaemic effect of a guar preparation which absorbs a particularly large amount of water has been examined in 13 patients with Type II hyperlipidaemia. A 30-day pre-treatment phase was followed by 60 days of treatment with 4 g guar dissolved in 200-ml liquid at each meal-time (total guar 12 g/day), and a 60-day post-treatment observation period. Routine other clinical blood tests were performed 30, 15 or 0 days before treatment, 15, 30 and 60 days after the start of treatment, and 30 and 60 days after its end.Total cholesterol fell by 0.85 mmol·l–1, from a pre-treatment concentration of 7.4 mmol·l–1 to a treatment value of 6.5 mmol·l–1, and LDL-cholesterol fell by 0.64 mmol·l–1, from 5.5 mmol·l–1 to a treatment value of 4.8 mmol·l–1. There was no significant change in triglyceride and VLDL concentrations during the study. A slight but significant fall in HDL-cholesterol was seen. The sole adverse effect was occasional intestinal discomfort. |
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Keywords: | cholesterol guar hyperlipidaemia HDL-/LDL-cholesterol |
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