HLA-DRB1*10与中国人慢性乙肝关联

目的研究ＨＬＡ－ＤＲＢ１基因与乙肝的关联，探讨可能由病毒感染继发的自身免疫反应导致疾病发展的主要原因，为乙肝的病因学及预后估计提供免疫学方面的资料。方法在我国北方地区随机选择５４名慢性乙肝患者，用ＰＣＲ／ＳＳＰ方法进行ＨＬＡ－ＤＲＢ１等位基因分型，对照组为同地区９２名健康人。采用疾病和ＨＬＡ相关分析软件进行数据处理。结果病人组ＨＬＡ－ＤＲＢ１＊１０基因频率明显增高为２５．９％（ＲＲ＝１０．３８，Ｐｃ＝０．００１），其它等位基因频率在实验组与对照组间差异无显著性。结论ＨＬＡ－ＤＲＢ１＊１０基因与中国北方人群慢性乙肝关联

The association of HLA-DRB1*10 with chronic hepatitis B in Chinese patients

Objective Hepatitis B is a common infectious disease in China. Probably the immunoreaction which is secondary to HBV infection is the main reason. The authors studied the association of HLA DRB1 alleles with hepatitis B in northern China, to provide some evidence of immunology for hepatitis B infection in pathogenesis and prognosis. Methods Fifty four northern Chinese patients of Han nationality affected with chronic hepatitis B were typed for HLA DRB1 genes with PCR SSP method. Results Compared to 92 matched controls, only DRB1*10 increased significantly in patient group. The frequency of DRB1*10 was 25 9% with RR=10 83, Pc=0 001 No significant different allele frequencies of other alleles were observed between the patient group and control. Conclusions The susceptibility to chronic hepatitis B is strongly associated with HLA DRB1*10 allele in northern Chinese patients.