叶酸保留灌肠治疗婴幼儿轮状病毒性肠炎

目的:探讨叶酸保留灌肠治疗婴幼儿轮状病毒性肠炎的疗效。方法:200例轮状病毒性肠炎患儿随机分为对照组、叶酸口服组、叶酸保留灌肠组及利巴韦林组,在对照组常规治疗的基础上,叶酸口服组给予叶酸5 mg/次,3次/d,连服3~5 d;叶酸灌肠组将叶酸片剂10~15 mg溶于15 mL生理盐水保留灌肠,1次/d,连用3 d;利巴韦林组将利巴韦林10~15 mg/(kg.d)溶于5%葡萄糖溶液中静脉滴注,1次/d;观察各组发热、呕吐、腹泻、脱水等临床表现消失时间,并比较疗效。结果:治疗72 h后对照组、叶酸口服组、叶酸灌肠组及利巴韦林组总有效率分别为59.6%、73.9%、91.4%及65.9%。其中,叶酸保留灌肠组总有效率均较其他三组高,差异有统计学意义(P<0.01或P<0.05)。叶酸保留灌肠可明显缩短患儿退热、止吐、止泻及脱水纠正时间。结论:在常规治疗基础上配合叶酸保留灌肠治疗婴幼儿轮状病毒性肠炎比常规治疗及常规治疗配合口服叶酸或静脉滴注利巴韦林效果好。

Curative effect of folic acid retention-enema on infants and preschool children with rotavirus enteritis

Objective:To discuss curative effect of folic acid retention-enema in treatment of infants and preschool children with rotavirus enteritis.Methods:Beside the control group,other three groups were respectively treated with oral folic acid,folic acid retention-enema and ribavirin iv drop.The extinction time of clinical manifestations such as fever,vomit,diarrhea and dehydration was observed for all patients with their curative effects compared between each groups.Results: After 72 hour treatment,the whole efficacy rate of each treatment group was respectively 59.6%,73.9%,91.4% and 65.9%,and the efficacy rates of folic acid retention-enema were evidently higher than those of ribavirin(P<0.01) and greater than those of oral folic acid(P<0.05).Compared with other groups,folic acid retention-enema could obviously shorten remedy times of fever,antiemetic,checking diarrhea and dehydration.Conclusions: Curative effect of folic acid retention-enema in addition to routine treatment on infants and preschool children with rotavirus enteritis is better than that of routine treatment,oral folic acid treatment or ribavirin iv drop.