1型血管紧张素Ⅱ受体基因多态性与2型糖尿病伴高血压的相关性

目的：探讨1型血管紧张素Ⅱ受体（AT1R）基因多态性与2型糖悄病伴高血压之间的相互关系。方法：以AT1R基因为候选基因，应用PCR方法，检测132例2型糖尿病伴高血压患者及107例2型糖尿病无高血压患者的AT1R基因多态性。结果：2组研究对象AA基因型分布频率分别为88．79％与96．97％，AC基因型分布频率分别为11．21％与3．03％，A等位基因携带率分别为94．39％与98．48％，C等位基因携带率分别为5．61％与1．52％，均有显著性差异（P＜0．05），提示AT1R基因多态性与2型糖尿病伴高血压的发生有相关性，且糖尿病伴高血压患者病程显著延长，正常血压糖尿病患者与单纯舒张压升高糖尿病患者之间AT1R－A1166－C基因多态性无显著差异，而与单纯收缩压升高糖尿病患者之间有显著性差异，结论：AT1R基因参与型糖悄病伴高血压的发病，并仅与收缩压升高有关。

Correlation between angiotensin II type 1 receptor gene polymorphism and type 2 diabetes mellitus complicated by hypertension.

OBJECTIVE: To elucidate the correlation between angiotensin II type 1 receptor (AT1R) gene polymorphism and type 2 diabetes mellitus (T2DM) complicated by hypertension. METHODS: AT1R gene polymorphism was determined by PCR in 132 T2DM patients complicated by hypertension and 107 normotensive T2DM patients. RESULTS: The frequencies of AA and AC genotypes in the 2 groups were 88.79% vs 96.97% and 11.21% vs 3.03% respectively, and those for A and C allele were 94.39% vs 98.48% and 5.61% vs 1.51%, showing significant difference between the 2 groups (P<0.05). It was suggested that AT1R gene polymorphism was associated with T2DM complicated by hypertension, and the patients had significantly prolonged courses of DM when complicated by hypertension. Normotensive DM patients did not differ from DM patients with only elevated diastolic blood pressure in terms of AT1R-A1166-C gene polymorphism, but showed significant difference from DM patients with elevated systolic blood pressure. CONCLUSION: AT1R gene contributed to T2DM complicated by hypertension, but is only associated with cases of elevated systolic blood pressure.