希明婷片治疗妇女围绝经期综合征的临床观察

目的:探讨希明婷片治疗妇女围绝经期综合征的有效性和安全性。方法:采用多中心、随机、开放、阳性对照研究方法,将60例围绝经期综合征患者随机分为实验组和对照组(倍美力组),应用KuppermanIndex量表,评价治疗前后潮热多汗、烦燥易怒、失眠等围绝经期症状评分值的改变及患者治疗前后血常规、尿常规、肝肾功能、激素水平、B超等变化。结果:治疗后两组患者的潮热多汗、烦燥易怒、失眠等症状总积分均低于治疗前,差异有统计学意义(P<0.05),两组间差异无统计学意义(P>0.05);治疗前后血常规、尿常规、肝肾功、血雌激素(E2)、卵泡刺激素(FSH)、子宫内膜厚度等改变两组患者均无统计学意义(P>0.05)。结论:希明婷治疗妇女围绝经期综合征有效安全。

The efficacy and safety of Ximingting tablets in the treatment of women with menopausal syndrome

Objective:To observe the efficacy and safety of Ximingting tablets in the treatment of woman with menopausal syndrome.Methods:The multi-centered,randomized,opened and positive controlled trial was established.Sixty patients with menopausal symptoms were randomly assigned into two parallel groups, the investigated group and the controlled group.The menopausal symptoms such as hot flushes,sweating,irritation,insomnia were observed before and after the treatment by Kupperman Index.The side effect,the changes of blood routine,urine routine,liver functions,kidney functions and the sonography before and after the treatment were also assessed.Results:The symptoms such as hot flushes,sweating,irritation and insomnia were improved after the treatment in two groups(P<0.05). There was no statistical significance between two groups (P>0.05).The changes of blood routine,urine routine,liver functions,kidney functions and the sonography before and after the treatment in two groups showed no statistical differences (P>0.05).Conclusion:Ximingting tablets is efficacious and safe in the treatment of woman with menopausal syndrome.