Inhibition of gastrointestinal motility by MPTP via adrenergic and dopaminergic mechanisms |
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Authors: | Yuval Haskel MD Dr Menachem Hanani PhD |
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Institution: | (1) From the Laboratory of Experimental Surgery, Hadassah University Hospital, Mount Scopus, 91240 Jerusalem, Israel |
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Abstract: | The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was injected intraperitoneally in mice and caused an acute inhibition (of over 60%) of gastrointestinal motility, which was measured by the transit of charcoal. This inhibition was not related to conversion of MPTP to MPP+. Administration of the -adrenergic blocker propranolol significantly reduced, but did not completely block, the effect of MPTP. The dopaminergic blocker haloperidol also partly reversed the effects of MPTP. When these blockers were administered together, the action of MPTP was fully blocked. The results indicate that the toxin acted by releasing catecholamines (presumably norepinephrine and dopamine), thereby inhibiting motility.Supported by a grant from the Joint Research Fund of the Hebrew University and Hadassah. |
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Keywords: | gastrointestinal transit adrenoceptors dopamine receptors 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine mouse |
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