| 腹膜透析液中头孢西丁钠的稳定性考察 |
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| 引用本文： | 姚立军,翁小红.腹膜透析液中头孢西丁钠的稳定性考察[J].抗感染药学,2011,8(3):201-203. |
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| 作者姓名： | 姚立军 翁小红 |
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| 作者单位： | 1. 苏州大学附属第一医院,江苏苏州,215006
2. 苏州市立医院,江苏苏州,215002 |
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| 摘 要： | 目的:考察注射用头孢西丁钠在25℃和37℃的腹膜透析液中的稳定性。方法:采用高效液相色谱法测定配伍液中头孢西丁钠的质量,并考察配伍液外观和pH值的变化。结果:头孢西丁钠与腹膜透析液配伍后8h内其外观、pH值及其质量均无明显变化。结论:头孢西丁钠在25℃和37℃的腹膜透析液中是稳定的;临用前须将腹膜透析液的温度温至37℃后再加入头孢西丁钠,以减少高温下头孢西丁钠的降解,确保安全用药。
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| 关 键 词： | 头孢西丁钠 腹膜透析液 高效液相色谱法 |
Stability of Cefoxitin Sodium in Peritoneal Dialysis Fluid |
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| YAO Li-jun,WENG Xiao-hong.Stability of Cefoxitin Sodium in Peritoneal Dialysis Fluid[J].Anti-infection Pharmacy,2011,8(3):201-203. |
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| Authors: | YAO Li-jun WENG Xiao-hong |
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| Institution: | YAO Li-jun1*,WENG Xiao-hong2 1No.1 Hospital Affiliated to Suzhou University,Suzhou Jiangsu 215002,China,2Municipal Hospital of Suzhou |
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| Abstract: | Objective： To study the stability of cefoxitin sodium for injection mixed with peritoneal dialysis solution at 25 ℃ and 37 ℃. Methods： The content of cefoxitin was determined by HPLC, the appearance of the solution was observed and its pH value was testsed. Results： There were no significant changes in appearance, pH value and content of the mixed solution within eight hours. Conclusion： Cefoxitin sodium mixed with peritoneal dialysis solution was basically stable. |
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| Keywords: | cefoxitin sodium peritoneal dialysis fluid HPLC |
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