苦黄缓释微丸的制备及其质量考察

目的:考察苦黄缓释微丸的制备及其质量指标。方法:利用流化床包衣设备,采用薄膜包衣法制备苦黄缓释微丸,以总蒽醌为指标性成分,测定缓释微丸的释放度,并考察了包衣处方工艺因素对药物释放的影响。结果:流化床薄膜包衣法成功制备了苦黄缓释微丸,其Eudragit RS 30D与Eudragit RL 30D的用量比例为1∶0时,包衣增重为14%;累积释放百分率2h26%,6h70%,12h90%。结论:水性薄膜包衣技术制备苦黄缓释微丸,具有良好的体外缓释行为。

Studies on Preparation and Quality Evaluation of Kuhuang Compound Sustained-release Micropellets

Objective:To prepare the sustained-release micropellets loading kuhuang compound extracts, a traditional chinese medicine, and to evaluate their quality. Methods: Kuhuang compound sustained-release micropellets were prepared by film-coating in a fluid-bed spray processor. The in vitro releases of the micropellets were determinated using total anthraquinone as a reference of effective components. Meanwhile, we investigated the influence of formulations for coating dispersion and coating process on the releas...