Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice |
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| Authors: | C L Sun F W Hui J P Hanig |
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| Institution: | Division of Drug Biology, Food and Drug Administration, Washington, DC 20204, U.S.A. |
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| Abstract: | Antinociception was assessed in male CD-1 mice by a modification of Haffner's tail-clamp procedure. The H1 blockers, including an ethylenediamine (pyrilamine), an ethanolamine (diphenhydramine), a phenothiazine (methdilazine), a piperazine (cyclizine) and an alkylamine (chlorpheniramine), all produced antinociception when given alone to mice and also caused potentiation when combined with morphine. |
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| Keywords: | antinociception morphine pyrilamine diphenhydramine methdilazine cyclizine chlorpheniramine |
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