强迫症患者认知功能特点的研究

目的了解强迫症患者的认知功能特点。方法以52例停药或首诊的强迫症患者为研究对象,均符合美国精神障碍诊断与统计手册第4版和中国精神障碍分类与诊断标准第3版强迫症诊断标准,以年龄、性别、受教育年限与强迫症组匹配的53名健康人作为正常对照组,采用神经心理测验分别对两组进行评定。结果强迫症患者的知识(1996±502)分]、算术(1405±231)分]、数字符号(5730±1241)个]、木块图形(3548±875)分]、逻辑即时记忆(930±412)个]、逻辑延迟记忆(667±437)个]、词语流畅性(2201±691)个]、划痕(6756±2723)s]、威斯康星卡片分类测验(3288±636)个]、汉诺塔测验成绩(5517±971)分]均差于正常对照组,分别为知识(2193±322)分、算术(1505±186)分、数字符号(6462±1058)个、木块图形(3862±709)分、逻辑即时记忆(1311±379)个、逻辑延迟记忆(1105±481)个、词语流畅性(2650±607)个、划痕(5412±1849)s、威斯康星卡片分类测验(3615±346)个、汉诺塔测验成绩(6194±919)分,均P<005和P<001;强迫症组和正常对照组的STCW正确数分别为(9024±2007)个和(9326±1592)个,STC和STCW的纠正数均为(0)个和(1)个,均P<005。结论强迫症患者存在广泛的认知功能损害,涉及注意、记忆、执行功能、语言和非语言表达等方面

The features of cognitive function in obsessive-compulsive disorder

Objective This research was to explore the features of cognitive function in patients with obsessive-compulsive disorder (OCD).Methods Fifty-two patients met with the 4th edition of Diagnostic and Statistical Manual of Mental Disorder and the 3rd edition of Chinese Classification and Diagnostic Criteria for Mental Disorders criteria for OCD and 53 age-, gender-, and education-matched normal controls were recruited in the study. A series of the neuropsychological tests including knowledge, mathematics, digit symbol, jigsaw puzzle, digit span, logical memory, visual memory, stroop test, verbal fluency, trial making A and B, tower of Hanoi and modified version of Wisconsin card sorting test was administered to the subjects.Results The patients performed significantly worse than the control on the tests of knowledge, mathematics, digit symbol, jigsaw puzzle, memory, verbal fluency, trial making test, tower of Hanoi and modified version of Wisconsin card sorting test (P<0.05). Conclusion It is suggested that a wide span of cognitive function be markedly impaired in patient with OCD.