慢性荨麻疹患者外周血T淋巴细胞检测的意义

目的:探讨慢性荨麻疹患者外周血T淋巴细胞水平变化的意义。方法:分别检测并比较正常人群与慢性荨麻疹患者外周血CD3+、CD3+CD4+、CD3+CD8+、CD3+CD4+/CD3+CD8+等指标水平情况;检测并比较慢性荨麻疹患者治疗前后治愈组、显效组、进步组及无效组外周血CD3+、CD3+CD4+、CD3+CD8+、CD3+CD4+/CD3+CD8+等指标水平变化情况。结果:慢性荨麻疹患者外周血CD3+、CD3+CD4+等指标明显低于正常组;CD3+CD8+、CD3+CD4+/CD3+CD8+与正常组无明显差异。治疗前后外周血CD3+、CD3+CD4+等指标水平明显变化,且CD3+、CD3+CD4+指标变化情况与疗效成正相关关系。结论:外周血T淋巴细胞可以作为观察临床疗效的有效指标。

The Influence on T-lymphocyte Subgroup in Patients with Chronic Urticaria

Objective:To observe the influence of T-lymphocyte subgroup in patients with chronic urticaria.Methods:Divide all the case into two groups:group one was normal group,the other was patient’s group.T-lymphocyte subgroup(including CD3+、CD3+CD4+、CD3+CD8+ and the ratio of CD3+CD4+/CD3+CD8+) was measured between two groups and conpared before and after treatment in patient’s group.Results:CD3+ and CD3+CD4+ in patient’s group were lower than normal group,and there were significant difference between two groups(P <0.05),while there were no significant difference in CD3+CD8+、the ratio of CD3+CD4+/CD3+CD8+(P >0.05).In patient’s group:CD3+、CD3+CD4+ were significant difference between before and after treatment,and can be negative correlation with curative effect.Conclusion:T-lymphocyte subgroup in patients with chronic urticaria might play an important role in clinical observation.