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Peripheral primitive neuroectodermal tumour after allogeneic bone marrow transplantation |
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| Authors: | Erick Gamelin Sylvie Francois Serge Guyetant Marie Christine Rousselet Pierre Pabot du Chatelard Jean Michel Coindre Norbert Ifrah |
| Institution: | Service d'Hématologie, Centre Regional et Universitaire (C.H.U.) d'Angers, France;Laboratoire d'Anatomie Pathologique, C.H.U, Angers, France;Centre Paul Papin, Centre Régional de Lutte contre le Cancer (C.R.L.C.C.), Angers, France;Institut Bergonié, C.R.L.C.C. Bordeaux, France |
| Abstract: | Summary. We report a case of peripheral primitive neuroectodermal tumour (PNET) in a 36-year-old man who 10 years earlier received an allogeneic bone marrow transplantation (BMT) for a non-Hodgkin's lymphoma. Immunohistochemistry proved definitive elimination of a relapse of the original disease and confirmed the diagnosis of PNET. The role of total body irradiation pre-BMT in the genesis of this secondary tumour is discussed. The importance of registering secondary malignant solid tumours after BMT is emphasized. To our knowledge, an Ewing family tumour following BMT has not previously been reported. |
| Keywords: | bone marrow transplantation peripheral primitive neuroectodermal tumour secondary malignant solid tumour |