| PTEN功能调节的研究进展 |
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| 引用本文： | 刘伦华,楼丽广.PTEN功能调节的研究进展[J].中国药理学通报,2005,21(7):778-781. |
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| 作者姓名： | 刘伦华 楼丽广 |
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| 作者单位： | 中国科学院上海生命科学研究院,上海药物研究所,上海,201203 |
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| 摘 要： | PTEN是具有蛋白与脂质磷酸酯酶活性的双特异性磷酸酯酶,能特异地使磷脂酰肌醇3,4,5三磷酸3′位脱磷酸,抑制PI3K/Akt信号转导途径,从而在细胞的生长、分化、凋亡、迁移等方面起着重要的调控作用。PTEN的异常与多种人类肿瘤如子宫内膜瘤、前列腺癌、乳腺癌等的发生、侵袭及转移密切相关。在细胞中,PTEN功能受到蛋白表达、磷酸化、氧化以及膜定位等因素的调节。该文就PTEN调节的分子机制作一综述。
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| 关 键 词： | PTEN Akt 磷酸酯酶 PI3K 抑癌基因 |
| 文章编号： | 1001-1978(2005)07-0778-04 |
| 修稿时间： | 2005年1月5日 |
Recent advance in the regulation of PTEN's function |
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| LIU Lun-hua,LOU Li-guang.Recent advance in the regulation of PTEN''''s function[J].Chinese Pharmacological Bulletin,2005,21(7):778-781. |
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| Authors: | LIU Lun-hua LOU Li-guang |
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| Abstract: | The tumor suppressor PTEN is a dual-specificity phosphatase possessing both protein phosphatase and lipid phosphatase activity. PTEN inhibits phosphatidylinositol-3-kinase (PI3-K)/ Akt signaling pathway by dephosphorylating phosphatidylinositol-(3,4,5)-triphosphate at the 3 site. PTEN plays a pivotal role in cell growth, proliferation, migration, and apoptosis. The deregulation of PTEN has been implicated in a variety of human cancers such as prostate, endometrial, and breast cancers. Cellular PTEN's function appears to be regulated by its expression, phosphorylation, oxidation, and membrane binding. This review summarized the current progress in the molecular mechanism of PTEN's function. |
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| Keywords: | PTEN Akt PI3K |
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