| Ras鸟苷酸结合蛋白超家族新成员RhoE/Rnd3 |
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| 引用本文： | 张翠艳,赫捷.Ras鸟苷酸结合蛋白超家族新成员RhoE/Rnd3[J].医学分子生物学杂志,2006,3(3):209-211. |
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| 作者姓名： | 张翠艳 赫捷 |
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| 作者单位： | 中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所胸外科实验室,北京市,100021 |
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| 摘 要： | RhoE/Rnd3是Ras鸟苷酸结合蛋白超家族的新成员,调节细胞骨架的重组,影响细胞的生长和迁移。核糖基转移酶C3Stau可以修饰并改变RhoE/Rnd3蛋白的活性,下游效应蛋白Soc ius、ROCK I以及p190 RhoGAP则参与信号的传导。RhoE/Rnd3与疾病,尤其是肿瘤的发生发展有关。
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| 关 键 词： | 鸟苷酸结合蛋白 信号传导 |
| 修稿时间： | 2005年10月26 |
RhoE/Rnd3-A Novel Member of Ras GTP Binding Protein Superfamily |
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| ZHANG Cuiyan,HE Jie.RhoE/Rnd3-A Novel Member of Ras GTP Binding Protein Superfamily[J].Journal of Medical Molecular Biology,2006,3(3):209-211. |
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| Authors: | ZHANG Cuiyan HE Jie |
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| Abstract: | RhoE/Rnd3 is a novel member of Ras GTP binding protein superfamily.It can regulate the cytoskeletal reorganization and influence the cell growth and migration.The ribosyltransferase C3~(Stau)can modify RhoE/Rnd3 and change its activity,while the downstream effectors Socius,ROCK I and p190 RhoGAP participate in the Rnd3 GTPase-induced signal transduction pathways.RhoE/Rnd3 is associated with the initiation and development of disease, particularly with cancer. |
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| Keywords: | GTP binding protein signal transduction |
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