Notch3在肿瘤发生发展中的作用

Notch信号通路是一个高度保守的信号通路，在脊椎动物发育过程中扮演重要角色。研究发现Notch受体介导的信号通路在多种肿瘤中异常表达。近年来研究表明Notch3与多种肿瘤的发生发展有着密切的联系，Notch3在调控肿瘤细胞的凋亡、增殖和分化中起着重要作用，本文就Notch3在各类常见肿瘤中的研究进展进行综述，重点探讨Notch3异常表达与肿瘤形成、发展的分子机制，以期推动Notch3作为药物作用靶点的研究。

The role of Notch3 in tumorgenesis and progression

Notch signaling pathway is a highly conserved signaling pathway ,and plays an important role in the individual growth and development process in the vertebrate .Many studies have demonstrated Notch 3 re-ceptor expression is aberrant in a variety of tumors .Recent studies show that aberrant Notch 3 mediated signaling pathway is closely related with the progression of diverse types of tumors .Notch3 plays a vital role in apoptosis , proliferation and differentiation of tumor cells .To promote the studies of Notch 3 as a drug development targets ,the molecular mechanisms of abnormal Notch 3 expression and its role on tumorgenesis ,progression and treatment re-sistance are reviewed in this paper .