| Toll 样受体4在恶性淋巴瘤中的作用 |
| |
| 引用本文： | 郭莉.Toll 样受体4在恶性淋巴瘤中的作用[J].实用肿瘤学杂志,2014(5):456-459. |
| |
| 作者姓名： | 郭莉 |
| |
| 作者单位： | 1. 哈尔滨医科大学附属肿瘤医院呼吸肿瘤科 哈尔滨 150081
2. 哈尔滨医科大学附属肿瘤医院乳腺肿瘤科 |
| |
| 摘 要： | 恶性淋巴瘤的发病机制一直是肿瘤研究的一个重要课题，但至今尚不完全明确。最近有临床研究表明TLR4（Toll－like receptor 4，TLR4）在套细胞淋巴瘤组织中和多种淋巴瘤细胞系中均有较高表达，且与预后有一定相关性。本文对TLR4在恶性淋巴瘤发生发展中的作用做一综述，以阐明淋巴瘤发病机制并为其治疗提供新的依据。
|
| 关 键 词： | Toll样受体4 恶性淋巴瘤 发病机制 |
The role of Toll-like receptor 4 in malignant lymphoma |
| |
| GUO Li,ZHANG Qingyuan.The role of Toll-like receptor 4 in malignant lymphoma[J].Journal of Practical Oncology,2014(5):456-459. |
| |
| Authors: | GUO Li ZHANG Qingyuan |
| |
| Institution: | GUO Li, ZHANG Qingyuan (1. Department of Respiratory Oneology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China ;2. Department of Breast Cancer, The Affiliated Tumor Hospital of Harbin Medical University) |
| |
| Abstract: | The pathogenesis of malignant lymphoma has been an important topic in tumor research ,but it is still unclear.Recent clinical studies showed that the expression level of Toll -like receptor 4（TLR4）was signif-icantly high in mantle cell lymphoma tissue and a variety of lymphoma cell lines .At the same time,the TLR4 ex-pression level was correlated with prognosis .The Role of TLR4 in malignant lymphoma for occurrence and devel-opment is reviewed in this article ,which may elucidate the pathogenesis and provide a new basis for the therapy of lymphoma. |
| |
| Keywords: | Toll-like receptor 4 Malignant lymphoma Pathogenetic mechanism |
| 本文献已被 维普 等数据库收录！ |
