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| 应用弥散张量成像研究脑梗死后皮质脊髓束Wallerian变性与运动功能缺损的相关性 | |
| 引用本文： | 方珉,周林江,谢瑞满.应用弥散张量成像研究脑梗死后皮质脊髓束Wallerian变性与运动功能缺损的相关性[J].中国临床神经科学,2009,17(1). |
| 作者姓名： | 方珉 周林江 谢瑞满 |
| 作者单位： | 1. 复旦大学附属华山医院放射科,200040;复旦大学附属中山医院神经内科,200032 2. 复旦大学附属华山医院放射科,200040;复旦大学上海医学院影像医学系 3. 复旦大学附属中山医院神经内科,200032 |
| 基金项目： | 复旦大学上海医学院青年骨干基金 |
| 摘 要： | 目的:应用弥散张量成像(DTI)研究脑梗死后皮质脊髓束Wallerian变性与神经运动功能缺损的相关性。方法:对11例单侧大脑中动脉供血区脑梗死的患儿进行了DTI研究。通过放置兴趣区(ROI)的方式获得定量部分各向异性(FA)和平均弥散量(MD)。ROI放置的部位包括:脑梗死区、脑梗死同侧内囊后支前部和大脑脚,以及上述部位对侧相应区域。根据手的运动情况将运动功能缺损分为轻、中和重3级。应用Mann-Whitney U检验确定差异有无显著性;应用Spearman相关检验确定皮质脊髓束DTI改变与神经运动功能缺损之间的相关性。结果:脑梗死同侧皮质脊髓束FA较对侧明显下降(P<0.05),但MD改变与对侧无明显差异(P>0.05)。FA下降与神经运动功能缺损之间存在明显相关性(r=-0.638,P=0.035)。结论:应用FA值的变化,DTI可以检测并定量分析儿童脑梗死后皮质脊髓束Wallerian变性,并可作为预测脑梗死后运动功能缺损的工具。 |
| 关 键 词： | 脑梗死 Wallerian变性 皮质脊髓束 弥散张量成像 神经运动功能 |
Evaluation of the Relationship Between Neuromotor Outcome and Wallerian Degeneration of Corticospinal Tract after Cerebral Infarction Using Diffusion-tensor MR Imaging |
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| FANG Min,ZHOU Ling-Jiang,XIE Rui-Man.Evaluation of the Relationship Between Neuromotor Outcome and Wallerian Degeneration of Corticospinal Tract after Cerebral Infarction Using Diffusion-tensor MR Imaging[J].Chinese Journal of Clinical Neurosciences,2009,17(1). | |
| Authors: | FANG Min ZHOU Ling-Jiang XIE Rui-Man |
| Institution: | FANG Min1; ZHOU Ling-Jiang2; XIE Rui-Man1 1 Department of Neurology; Zhongshan Hospital; Fudan University; Shanghai 200032; 2 Department of Radiology; Huashan Hospitai; Shanghai 200040; China; |
| Abstract: | Aim:To evaluate the relationship between neuromotor outcome and Wallerian degeneration of corticospinal tract after cerebral infarction using Diffusion-tensor MR imaging.Methods:Eleven children with MCA stroke were studied with diffusion-tensor MRI.Quantitative FA and MD,obtained by manually placing regions-of-interest(ROI) within the infarction,and along the ipsilateral corticospinal tract,i.e.the posterior limb of the internal capsule and cerebral peduncle,were compared with matched contralateral regions ... |
| Keywords: | infarction Wallerian degeneration corticospinal tract diffusion-tensor MR imaging neuromotor outcome |
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