RU486配伍米索前列醇中止瘢痕子宫早孕的安全性及可行性探讨

采用RU486配伍米索前列醇中止早孕188例，其中27例为瘢痕子宫。结果显示188例用药后完全流产率为91．48％；27例瘢痕子宫组为100％；161例非瘢痕子宫组为90．06％，两组完全流产率的差异无显著性意义，P>0．05，且两者绒球排出时间及出血时间亦无明显差异，瘢痕子宫组无一例严重并发症。提示RU486配伍米索前列醇口服中止瘢痕子宫早孕者安全、有效，并非其禁忌证，推荐为首选方法之一。

Study on Safety and Feasibility of Termination of Early Pregnancy with Cicatrix Uterus by Combined Use of Mifepristone and Misoprostol

To study the safety and feasibility of Mifepristone combined with Misoprostol terminating early pregnancy after cesarean section, mifepristone combined with misoprostol was used to terminate early pregnancy in 188 women requesting medical abortion. Among them, 27 cases were uterine cicatrix. The results showed that the complete abortion rate in 188 cases was 91.48 % after administration, that in 27 cases of unterine cicatrix was 100 % and that in 161 cases of no uterine cicatrix was 90. 06 % (P＞0. 05). There were no differences in the duration of vaginal bleeding and time from the Misoprostol intake to the expulsion of gestational sac and chorionic villi between the two groups (P＞0. 05). It was suggested that combined administration of Mifepristone and Misoprostol to terminate early pregancy is safe and effective after cesarean section.