急性心肌梗死患者超敏C反应蛋白和N末端-脑钠肽前体的临床观察

目的：探讨急性心肌梗死（AMI）患者急性期超敏C反应蛋白（hs—CRP）和N-末端脑钠肽前体（NT—pmBNP）水平及其临床意义。方法：将AMI患者76例分为ST段抬高急性心肌梗死（STEMI组，n=53）和非ST段抬高急性心肌梗死（NSTEMI组，n=23），并以健康者对照（c组，n=20），就诊时立即检测血浆hs-CRP浓度和NT—proBNP水平。结果：STEMI组血浆hs—CRP、NT-proBNP均显著高于NSTEMI组和对照组（P〈0．01）。结论：AMI患者血浆hs—CRP和NT—proBNP水平在急性期显著升高，并与心肌缺血的严重程度相关。

Clinical Observation of High Sensitivity C-reactive Protein and N-terminal Pro-brain Natriuretic Peptide in Patients with Acute Myocardial Infarction

Objective： To explore the levels and clinical significance of high sensitivity C-reactive protein （hs- CRP） and plasma N-terminal pro-brain natriuretic peptide （NT-proBNP） in patients with acute myocardial infarction （AMI）. Methods： 76 patients with AMI were divided into STEMI group（n=53） and NSTEMI group（n=23）, while healthy adult as control group（n=20）, hs-CRP and NT-proBNP were measured immediately after the patients with AMI arriving the emergency room. Results： Compared with the control group and NSTEMI group,plasma hs-CRP, NT- proBNP significantly increased in STEMI group （P〈0.01）. Conclusion： The hs-CRP and NT-proBNP elevated on the early stage in patients with AMI, and had a positive correlation to the degree of the myocardial ischemia.