亚胺培南／西司他丁钠治疗重症肺炎的疗效观察

目的：观察亚胺培南／西司他丁钠治疗重症肺炎的临床疗效及安全评价。方法：将2008年6月-2012年12月收治90例重症肺炎患者随机分为A、B、C三组各30例，分别使用亚胺培南／西司他丁钠1000mg静脉滴注，每8小时一次；500mg静脉滴注，每6小时一次；500mg静脉滴注，每8小时一次治疗，比较其临床疗效、细菌清除率和安全性。结果：A组、B组的临床疗效、细菌清除率和安全性均明显优于c组，P均〈0．05；但A组、B组间无显著性差异。结论：亚胺培南／西司他丁钠对重症肺炎有良好疗效，使用方法以500mg，静脉滴注，每6小时一次为最适宜。

Efficacy Observation of Severe Pneumonia Treated by Different Doses of Imipenem and Cilastatin Sodium

Objective： To observe the efficacy and safety evaluation of severe pneumonia treated by Imipenem and Cilastatin Sodium. Method： 90 patients with severe pneumonia were randomly divided into group A, group B and group C,each group was 30 cases from Jun 2008 to Dec 2012. Group A was Imipenem and Cilastatin Sodium 1000 mg intravenously every 8 hours, Group B was treated by Imipenem and Cilastatin sodium 500 mg intravenously every 6 hours, Group C was treated by Imipenem and Cilastatin sodium 500 mg intravenously every 8 hours.The clinical efficacy, the rate of bacterial clearance and safety were compared among the three groups.Results ： The clinical efficacy, the rate of bacterial clearance and safety in the group A and the group B were significantly better than those in the group C, all P〈0.05. But there were no difference between the group A and the group B. Conclusion：It has a good effect of severe pneumonia treated by Imipenem and Cilastatin Sodium and the best using method is 500mg intravenously every 6 hours.