|
|||||
|
|
Antibodies to skeletal muscle in myasthenia gravis: Part 3. Relation with clinical course and therapy |
|
| Authors: | JBM Kuks PC Limburg G Horst HJGH Oosterhuis |
| Institution: | a Department of Neurology, University Hospital Groningen, Groningen, The Netherlands b Department of Rheumatology, University Hospital Groningen, Groningen, The Netherlands c Department of Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands |
| Abstract: | Fluctuations of anti skeletal muscle antibodies (AMA) were studied in relation to clinical changes and fluctuations in anti acetylcholine receptor antibodies (a-AChR). Forty-two patients with generalized myasthenia gravis were studied in clinical and serological follow-up during several years under various conditions. Results from this study demonstrate that AMA fluctuate in strong relation to a-AChR, clinical course and immunosuppressive therapy. Thymomectomy resulted in an increase or de novo appearance of AMA in 10 of the 12 patients who did not receive immunosuppressive medication. |
| Keywords: | Myasthenia gravis Anti-skeletal muscle antibodies Follow-up Clinical course Anti-acetylcholine receptor antibodies Thymectomy Immunomodulating drugs |
| 本文献已被 ScienceDirect 等数据库收录！ | |