非酒精性脂肪性肝病患者血清脂联素水平及与酶学指标的相关性

目的通过检测非酒精性脂肪性肝病(NAFLD)患者血清脂联素及肝脏酶学等生化指标,探讨NAFLD患者血清脂联素水平与肝脏酶学等指标变化的相关性。方法选取60例NAFLD患者及60名健康对照者,用酶联免疫吸附试验法测定血清脂联素水平,结合患者的临床情况及肝脏酶学等指标,采用t检验和相关分析进行数据分析。结果NAFLD组血清脂联素水平为(12.7±2.8)mg/L,明显低于健康对照组(P<0.01);Spearman分析示脂联素与丙氨酸转氨酶(ALT)(r=-0.643,P<0.05)、天冬氨酸转氨酶(AST)(r=-0.472,P<0.05)、谷氨酰转肽酶(GGT)(r=-0.489,P<0.05)、甘油三酯(TG)(r=-0.671,P<0.05)、空腹血糖(FBG)(r=-0.710,P<0.05)、腰臀比(WHR)(r=-0.732,P<0.05)、体质量指数(BMI)(r=-0.719,P<0.05)呈负相关,与高密度脂蛋白胆固醇(HDL-C)(r=0.567,P<0.05)呈正相关。Logistic多因素回归分析显示脂联素与BMI(β=-0.314,P<0.05)呈独立负相关。结论NAFLD患者血清脂联素水平降低,其可能是NAFLD发病过程中起保护作用的脂肪细胞因子。

The level of adiponectin in serum and the changes of liver enzymes in nonalcoholic liver disease patients

Objective To investigate the correlation between the level of adiponectin and the enzymes of the liver in nonalcoholic liver disease (NAFLD) patients.Methods A total of 120 cases were enrolled and divided into two groups:NAFLD group (n=60),normal control group (n=60).The level of adiponectin in the serum was measured by ELISA.Combining the clinical representation and the indexes of the liver enzymes,t-test and correlation analysis were used to analyze the data.Results The serum adiponectin level in NAFLD gr...