肺性脑病患者血清神经元特异性烯醇化酶活性的研究

对１５例慢性肺心病合并肺性脑病患者及１０例无肺性脑病的肺心病患者血清神经元特异性烯醇化酶活性进行测定。结果显示：中、重型肺性脑病患者血清ＮＳＥ活性较轻型肺性脑病、治疗缓解后及对照组患者明显增高；且血清ＮＳＥ活性与动脉血氧分压呈负相关，与二氧化碳分压呈正相关。

Study of plasma neuron-specific enolase activity of patients with chronic pulmonary heart disease complicated by pulmonary encephalopathy]

The plasma neuron-specific enolase (NSE) activity in the 15 patients of chronic pulmonary heart disease complicated by pulmonary encephalopathy and 10 chronic pulmonary heart disease without pulmonary encephalopathy (controls) were detected. The results showed that NSE activity in patients with moderate, severe pulmonary encephalopathy were significantly higher than those of patients with mild pulmonary encephalopathy, stable patients and controls. The plasma NSE activity from the patients with pulmonary encephalopathy were negatively correlated with the PaO2 and were positively correlated with PaCO2. This study suggests that plasma NSE activity may reflect the degree of brain damage by chronic hypoxia and remain of CO2 in the patients with chronic pulmonary heart disease.