| CYP3A5基因多态性分析指导肾移植术后他克莫司的个体化用药 |
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| 引用本文： | 吕慧怡,范青,马辉,张宁,张策. CYP3A5基因多态性分析指导肾移植术后他克莫司的个体化用药[J]. 中国医院药学杂志, 2010, 0(4) |
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| 作者姓名： | 吕慧怡 范青 马辉 张宁 张策 |
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| 作者单位： | 大连医科大学附属第二医院药剂科; |
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| 基金项目： | 大连医科大学附属第二医院青年基金资助项目(编号:2007-10) |
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| 摘 要： | 目的:研究肾移植术患者CYP3A5基因多态性与术后个体化给药剂量的关系。方法:采用等位基因特异扩增法对27例肾移植术后患者进行CYP3A5基因分型。采用酶联免疫法测定他克莫司的血药浓度。比较不同基因型之间的他克莫司的血药浓度与给药剂量(C/D)比值的差异。结果:肾移植患者CYP3A5(A6986G)基因多态性,CYP3A5*3的发生频率为50%,CYP3A5*1/*3基因型与*1/*1基因型患者C/D比值相比差异无显著性(P>0.05),但两者C/D比值均显著低于*3/*3基因型患者(P<0.05)。结论:肾移植患者的CYP3A5基因多态性与他克莫司血药浓度具有相关性,CYP3A5*1/*3基因型和*1/*1基因型患者拟取得相似的血药浓度要比*3/*3型患者需服用更高剂量的他克莫司。分析肾移植患者的CYP3A5基因多态性与血药浓度关系,可指导其术后他克莫司的个体化用药方案。
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| 关 键 词： | 他克莫司 特异性等位基因扩增法 血药浓度/剂量 |
Analysis of CYP3A5 genetic polymorphism in kidney-transplanted patients to guide individual dosage regimen of tacrolimus administered after operation |
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| LU Hui-yi,FAN Qing,MA Hui,ZHANG Ning,ZHANG Ce. Analysis of CYP3A5 genetic polymorphism in kidney-transplanted patients to guide individual dosage regimen of tacrolimus administered after operation[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(4) |
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| Authors: | LU Hui-yi FAN Qing MA Hui ZHANG Ning ZHANG Ce |
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| Affiliation: | LU Hui-yi,FAN Qing,MA Hui,ZHANG Ning,ZHANG Ce (Department of Pharmacy,the Second Affilitaed Hospital of Dalian Medical University,Liaoning Dalian 116027,China) |
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| Abstract: | OBJECTIVE To research whether CYP3A5 genetic polymorphism in kidney-transplanted patients were associated with blood concentration/administration dose of tacrolimus.METHODS 27 kidney-transplanted patients treated with tacrolimus were enrolled in this study.To establish ploymerase chian rection and allele-specific amplification(ASA) for study the distribution of CYP3A genetic polymorphism in 27 kidney-transplanted patients,and the blood concentration of tacrolimus was tested by enzyme linked immunosorbent as... |
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| Keywords: | tacrolimus allele-specific amplification blood concentration/administration dosage |
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