儿科血分离菌株及其抗生素敏感性的研究

目的:了解儿科血分离菌株及其抗生素敏感性特点。方法:湖北地区15所医院1999~2003年临床儿科血分离菌株用纸片扩散法进行药敏试验。结果:儿科血分离菌株最常见的前6位病原菌是凝固酶阴性葡萄球菌(54.8%)、金黄色葡萄球菌(16.1%)、伤寒沙门菌(6.5%)、肠球菌(2.7%)、大肠埃希菌(1.8%)和克雷伯菌属(1.7%)。万古霉素是G+菌最为敏感的抗生素,其次是头孢唑啉;亚胺培南对G-菌最敏感,其次为头孢他啶。结论:儿科菌血症以G+菌感染为主,临床抗生素经验用药应以当地的细菌耐药性监测资料为依据。

Study on frequency of occurrence and antimicrobial susceptibility of bacteria isolated from blood in pediatric patients

Objective:To study the frequency of occurrence and antimicrobial susceptibility of bacteria isolated from blood in pediatric patients.Methods:Antimicrobial susceptibility of all bloodstream strains of pediatric patients isolated from 1999 to 2003 in 15 hospitals in Hubei province were testd by disc diffusion methodology.Results:The six most frequently isolated species were: coagulase-negative staphylococci(54.8%),staphylococcus aureus(16.1%),S.typhi (6.5%),enterococci(2.7%),E.coli(1.8%) and klebsiella sp.(1.7%).Vancomycin was the most effective antibiotic against Gram-positive organisms,which was followed by cefazolin.Imipenem was the most effective antibiotic against Gramnegative organisms,which was followed by ceftazidime.Conclusion:Gram-positive organisms are frequent and predominate in children bacteremia.The empirical antibiotics treatment should be based on the information of surveillance of microbial pathogens and their drug-resistance in local area.