Studies with a pathogenic and an attenuated strain of Venezuelan equine encephalitis virus and aedes aegypti (L.) mosquitoes |
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Authors: | Manfred Mussgay Octavio Suárez |
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Institution: | (1) Departamento de Virología, Instituto Venezolano de Investigaciones Científicas (I. V. I.C.), Apartado 1827, Caracas, Venezuela |
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Abstract: | Summary Venezuelan equine encephalitis virus was passaged in KB cell cultures. The virus lost its mouse pathogenicity following subcutaneous inoculation during KB cell passage; the attenuated strain also produced smaller plaques than the pathogenic strain. Both strains grew to the same extent inAedes aegypti (L.) mosquitoes after intrathoracic inoculation. If any reversions to pathogenicity occur during development of the attenuated virus in mosquitoes, then the mutation frequency per duplication per particle must be smaller than 3.5×10–6. |
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