清开灵联合颅脑降温仪治疗大面积脑梗死高热的效果观察

目的　探讨清开灵联合颅脑降温仪 (HTI)治疗大面积脑梗死 (LCI)高热的效果。方法　 97例病人 ,随机分为两组 ,观察组 5 3例 ,在脱水、对症、支持等治疗的同时 ,清开灵注射液 3 0ml加入 0 .9%盐水 10 0ml中 ,静脉滴注 ,1次 /d ,连续 7d ;同时应用颅脑降温治疗仪进行头部低温治疗 ,当病人体温恢复到 3 7.5℃以下 2～ 3d为终止治疗时间。对照组 44例 ,除不加用清开灵及HTI外 ,其它治疗方法同观察组。结果　两组比较 ,3d体温恢复率观察组明显高于对照组 (P <0 .0 5 ) ;体温反复率及病死率显著低于对照组 (P <0 0 1,P <0 .0 5 ) ;生存者NDS ,ADL明显优于对照组 (P <0 0 5 ,P <0 .0 1)。结论　清开灵联合颅脑降温仪治疗LCI高热 ,可明显改善预后和降低病死率

Observation of Therapeutic Effect of Qingkailing Plus HTI on High Fever Resulting from Large Cerebral Infarction

Objective To discuss the therapeutic effect of Qingkailing injection, which was made from traditional Chinese drugs, plus head temperature-decreasing instrument (HTI) on high fever resulting from large cerebral infarction. Methods All the 97 patients were divided into two groups, i.e. observing group and control group. In addition to routine dehydrating and supporting therapy, the former group consisting of 53 patients was administered with Qingkailing (30ml injection added to 100ml physiological saline solution, intravenous drip, once per day) plus HTI for seven days. Only routine therapy did the latter group consisting of 44 patients accepted.Results The rate of recovery from fever was significant higher in the observing group than that in the control group in three days (P<0.05), and recurrent rate of fever and death rate of the former group clearly lower than that of the latter group (P<0.01, P<0.05, respectively). More ideal survivors' neuropathy disability score (NDS) and activities of daily living (ADL) existed in the observing group than in the control group (P<0.05, P<0.01, respectively). Conclusion Not only better prognosis but also lower mortality can be reached when Qingkailing plus HTI is administered on high fever cases resulting from large cerebral infarction.