乳腺原发性恶性淋巴瘤3例

目的 探讨乳腺原发性恶性淋巴瘤组织学类型、临床病理特点及鉴别诊断。方法 收集3例乳腺原发性恶性淋巴瘤临床病理资料，对其进行HE染色和免疫组化标记。结果 3例乳腺原发性恶性淋巴瘤，2例为弥漫性大B细胞淋巴瘤，1例为粘膜相关淋巴组织淋巴瘤；LCA、CD20和bcl-2染色均为阳性，AEI／AE3、CIM5RO、CD10和bcl-6阴性。结论 乳腺原发性恶性淋巴瘤罕见，诊断主要依靠病理组织形态学和免疫组织化学标记。

Primary lymphoma of the breast:a review of 3 cases

Objective To investigate histologic subtypes, clinical pathological features and differential diagnosis in primary malignant lymphoma of the breast(PLB).Methods Three cases of PLB were analysed about clinical data,histopathology and immunohistochemistry.Results Three cases of PLB,2 cases were of DLBCL,1 case of MALToma.Immunohistochemistry showed that LCA,CD20 and bc1-2 in tumor cells were positive,which AE1/AE3,CD45RO and CD10 were negative.Positive cells that expressed bcl-6 scattered in MALToma.Conclusion PLB is a rare disease.Its diagnosis mainly depends on histopathology and the marker of immunohistochemistry.