Long-term smoking and ethanol exposure accentuates oxidative stress in hearts of mice |
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Authors: | Rajat Sandhir PhD Supriya Subramanian Ashwani Koul |
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Institution: | (1) Department of Biochemistry Medical Science Building, Panjab University, 160014 Chandigarh, India;(2) Department of Biophysics, Panjab University, Basic Medical Science Building, 160014 Chandigarh, India |
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Abstract: | The present study was undertaken to investigate the influence of ethanol on the cardiac antioxidant defense system of mice
exposed to cigarette snoke. Cigarette smoke exposure for 10 wk led to an increase in the levels of lipid peroxidation in the
heart. These levels increased further in animals co-exposeds to ethanol and cigarette, smoke. Concomitantly, the levels of
glutathione were found to decrease after cigarette smoke exposure. In the animals co-exposed to ethanol and cigarette smoke,
there was a further decrease in glutathione levels. Catalase activity increased in the animal sexposed to cigarette smoke;
this activity increased further with combined exposed to cigarette smoke and ethanol. On the other hand, superoxide dismutase
(SOD) activity was not affected by cigarette smoke exposure, while it increased in the ethanol-exposed group. SOD activity
was higher in the hearts of animals co-exposed to cigarette smoke and ethanol as compared to animals that received ethanol
alone. The actvity of heat-stable lactate dehydrogenase in serum was not affected when the animals were exposed to either
cigarette smoke or ethanol, whereas this activity was observed to be, elevated in animals co-exposed to cigarette smke and
ethanol. It appears from these results that ethanol potentates the cigarette-smoke-induced peroxidative damage to heart. |
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Keywords: | Cigarette smoke ethanol heart oxidative stress antioxidant defense system |
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