| Abstract: | Summary It was established that nucleic acids (NA) ofP.
pestis possess a specific property of stimulating the immunity in guinea pigs and monkeys in conjoint administration with the live EB vaccine. Conjoint immunization with the live vaccine and NA protected the animals against experimental bubonic (guinea pigs) and pulmonary plague (monkeys). NA ofP.
pestis causes no marked immunity in the animals without the live vaccine. Nucleoprotein (NP) and fraction I ofP.
pestis, as well as killed microbes of the EB strain, sodium nucleate, and NA ofBr.
melitensis, administered together with the live vaccine caused no stimulating effect on the formation of plague immunity in guinea pigs. Fraction I and NA ofP.
pestis, as well as sodium nucleate, obtained from yeast in doses and ratios to the live vaccine, depressed the development of immunity to this injection in guinea pigs.(Presented by Active Member AMN SSSR N. N. Zhukov-Verezhnikov) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 55, No. 1, pp. 77–80, January 1963 |
