| 毒理基因组学在生物标志物研究中的应用 |
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| 引用本文： | 周晓冰,汪巨峰,李波. 毒理基因组学在生物标志物研究中的应用[J]. 医学教育探索, 2012, 35(2): 81-85 |
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| 作者姓名： | 周晓冰 汪巨峰 李波 |
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| 作者单位： | 中国食品药品检定研究院 国家药物安全评价监测中心，北京 100176 |
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| 基金项目： | 中国食品药品检定研究院中青年发展研究基金（2011C3） |
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| 摘 要： | 近年来，毒理基因组学的快速发展为生物标志物的研究提供了一个更广阔的空间。生物标志物作为一种可以客观衡量和评价正常生理、病理过程及治疗药物药理学效应的指标，如今已被广泛应用于临床诊断和新药开发等多个领域。就毒理基因组学在发现和筛选生物标志物方面的研究现状和进展进行综述。
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| 关 键 词： | 毒理基因组学；生物标志物；药物；毒性 |
| 收稿时间： | 2012-03-04 |
Application of toxicogenomics on vesearch of biomarker |
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| ZHOU Xiao-bing,Wang Ju-feng,LI Bo. Application of toxicogenomics on vesearch of biomarker[J]. Researches in Medical Education, 2012, 35(2): 81-85 |
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| Authors: | ZHOU Xiao-bing Wang Ju-feng LI Bo |
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| Affiliation: | National Center for Safety evaluation of Drugs, National Institutes for Food and Drug Control, Beijing 100176 |
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| Abstract: | Toxicogenomics has recently been developed greatly, and it has contributed a lot on identifying potential biomarkers of toxicity. Biomarker is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, and pharmacologic responses to a therapeutic intervention. Nowadays, biomarkers have already been used widely at clinical diagnosis and investigation of new drugs. The progression of application of toxicogenomics on discovery and Screening of biomarker is reviewed. |
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| Keywords: | toxicogenomics biomarkers drug toxicity |
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