紫杉醇持续滴注联合方案二线治疗难治性晚期食管鳞癌 |
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引用本文: | 林岩,成红艳,顾明,李苏宜.紫杉醇持续滴注联合方案二线治疗难治性晚期食管鳞癌[J].肿瘤学杂志,2010,16(11):889-891. |
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作者姓名: | 林岩 成红艳 顾明 李苏宜 |
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作者单位: | [1]南京医科大学第二附属医院,江苏南京210011 [2]东南大学医学院附属中大医院,江苏南京210009 [3]东南大学医学院附属盐城医院,江苏盐城224001 |
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基金项目: | 南京医科大学科技发展基金重点项目 |
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摘 要: | 目的]研究含紫杉醇(PTX)持续静脉滴注方案二线治疗晚期食管癌的疗效和毒性。方法]26例晚期食管鳞癌患者应用含低剂量PTX持续静脉输注联合方案化疗:PTX20mg/m2,civ,16h,d1~3,d8~9;DDP3.75mg/m2,iv,d1~4,d8~11;5-Fu375mg/m2,civ,24h,d1~5,d8~12;叶酸60mg,po,d1~5,d8~12;21d为1个周期,至少应用2个周期。结果]23例完成2个周期治疗者可评价疗效,CR1例,PR9例,SD10例,PD3例,有效率为43.5%,中位疾病进展时间(TTP)5.1个月。主要毒副反应为骨髓抑制和脱发,其他毒副反应较轻。结论]低剂量PTX持续静脉输注联合方案治疗晚期食管鳞癌安全有效。
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关 键 词: | 食管肿瘤 紫杉醇 持续静脉滴注 顺铂 氟尿嘧啶 药物疗法 |
Continuous Intravenous Infusion Paclitaxel Based Combination Regimen as Second Line Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma |
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Institution: | LIN-Yan,CHENG Hong-yan,GU Ming,et al.(1.The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;2.Zhongda Hospital,Southeast University,Nanjing 210009,China;3.Yancheng Hospital,Southeast University,Yancheng 224001,China) |
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Abstract: | Purpose] To investigate the response and toxicity of continuous intravenous infusion paclitaxel based combination regimen as second line chemotherapy for advanced esophageal squamous cell carcinoma(ESCC).Methods] Twenty-six with ESCC pathologically proved received continuous intravenous infusion paclitaxel(PTX) based combination regimen.The regimen schedule was:PTX 20mg/m2,civ,16h,d1-3,d8-9;DDP 3.75mg/m2,iv,d1-4,d8-11,5-Fu 375mg/m2,civ,24h,d1-5,d8-12;folic acid 60mg,po,d1-5,d8-12.Twenty-one days as a cycle,and each patient was treated at least two cycles.Results] Response was evaluable in 23 cases with≥2 cycles,1 case in CR,9 cases in PR,10 cases in SD and 3 cases in PD,the overall response rate was 43.5%.The median TTP was 5.1 months.The main toxicities were myelosuppression and alopecia,and other toxicities were mild.Conclusion] Continuous intravenous infusion paclitaxel based combination regimen for advanced ESCC is effective and tolerable. |
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Keywords: | esophageal neoplasm paclitaxel continuous intravenous infusion cisplatin fluorouracil drug therapy |
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