| CD147和MMP9在乳腺浸润性导管癌中的表达及意义 |
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| 引用本文： | 党秋红,曾宪旭,张欢欢,班振英,楚天骄,王玉萍,李道明. CD147和MMP9在乳腺浸润性导管癌中的表达及意义[J]. 肿瘤学杂志, 2010, 16(9): 721-724 |
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| 作者姓名： | 党秋红 曾宪旭 张欢欢 班振英 楚天骄 王玉萍 李道明 |
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| 作者单位： | [1]郑州大学第三附属医院,河南郑州450052 [2]郑州大学基础医学院,河南郑州450052 |
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| 摘 要： | [目的]探讨CD147和MMP9在乳腺浸润性导管癌中的表达及意义。[方法]应用免疫组织化学方法SP法检测60例乳腺浸润性导管癌及60例乳腺纤维腺瘤组织中CD147和MMP9的表达情况。[结果]CD147及MMP9在60例乳腺纤维腺瘤中均阴性表达,CD147、MMP9在乳腺浸润性导管癌中的阳性表达率分别为91.7%（55/60）和86.7%（52/60）（P均=0.000）。CD147和MMP9的表达均与乳腺浸润性导管癌患者的组织学分级及淋巴结转移相关,与年龄、肿瘤大小、家族史及临床分期无关。CD147和MMP9在乳腺浸润性导管癌中表达呈显著性相关（r=0.830）。[结论]CD147和MMP9在乳腺浸润性导管癌中高表达,两者在乳腺癌的发生发展中发挥着重要作用。
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| 关 键 词： | 乳腺肿瘤 浸润性导管癌 CD147 MMP9 |
Expression of CD147 and MMP9 in Breast Invasive Ductal Carcinoma and its Significance |
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| Affiliation: | DANG Qiu-hong,ZENG Xian-xu,ZHANG Huan-huan,et al.(1.The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;2.Basic Medical College of Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | [Purpose] To investigate expression of CD147 and MMP9 in breast invasive ductal carcinoma and its significance. [Method] The expressions of CD147 and MMP9 in 60 cases with breast invasive ductal carcinoma and 60 cases with breast fibroadenoma were detected by immunohistochemical SP method. [Results] In 60 specimens with breast fibroadenoma,CD147 and MMP9 were all negative. The expressions of CD147 and MMP9 in breast invasive ductal carcinoma were 91.7%（55/60） and 86.7%（52/60）（all P=0.000） . The expressions of CD147 and MMP9 in breast invasive ductal carcinoma were related to histological grade,lymph node metastases and not related to age,tumor size,family history and clinical stage. Expression of CD147 was positively correlated to MMP9（r=0.830） . [Conclusion] CD147 and MMP9 were over expression in breast invasive ductal carcinoma,they play an important role in carcinogenesis of breast cancer. |
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| Keywords: | breast neoplasms invasive ductal cancer CD147 MMP9 |
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