| 周期蛋白6在DNA复制、细胞周期检测点和肿瘤发生发展中的作用 |
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| 引用本文： | 张佳华,黄士昂. 周期蛋白6在DNA复制、细胞周期检测点和肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2009, 36(1): 411-414. DOI: 10.3760/cma.j.issn.1673-422X.2009.06.004 |
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| 作者姓名： | 张佳华 黄士昂 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院干细胞中心,武汉,430022; |
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| 基金项目： | 国家杰出青年基金资助项目国家自然基金青年基金资助项目 |
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| 摘 要： | 周期蛋白6(CDC6)是组成前复制复合物(Pre-RC)的主要蛋白之一,控制细胞从G1期进入S期,同时也参与激活和维持有丝分裂S-M期检测点机制.最近的研究发现其也具有原癌基因的特性,并在人多种肿瘤细胞中存在高表达,对肿瘤发生发展起重要作用.CDC6致癌机制可能与INK4/ARF连结物信号途径和(或)某些替代机制有关.
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| 关 键 词： | 复制 肿瘤 |
Role of CDC6 in DNA replication, cell cycle checkpoints, tumorigenesis and tumor progression |
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| Abstract: | Cell-division cycle 6 (CDC6) is one of the major proteins consisting pre-replicative complexes(Pre-RC). It controls cells cycle from G1 phase into S phase, and participates in the activation and maintenance of S-M phase checkpoint mechanisms of mitosis. Recent studies have unveiled its proto-oncogenic activity and overexpression in many kinds of human cancer cells, and it plays an important role in tumorigenesis and tumor progression.CDC6-driven oneogenesis may be related with INK4/ARF link and/or some alternative mechanisms. |
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| Keywords: | CDC6CDC6ReplicationNeoplasms |
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