| 2种人卵巢癌裸鼠移植瘤模型的生物学特性比较研究 |
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| 引用本文： | 蒲才秀,常淑芳,孙江川,刘红霞,朱轶,陈佳.2种人卵巢癌裸鼠移植瘤模型的生物学特性比较研究[J].重庆医科大学学报,2011,36(11):1343-1346. |
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| 作者姓名： | 蒲才秀 常淑芳 孙江川 刘红霞 朱轶 陈佳 |
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| 作者单位： | 重庆医科大学附属第二医院妇产科,重庆,400010 |
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| 基金项目： | 国家自然科学基金资助项目(编号:30801228); 重庆市自然科学基金资助项目(编号:CSTC,2008BB5405); 重庆市卫生局资助项目(编号:07-2-098) |
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| 摘 要： | 目的:建立人卵巢癌裸鼠腹腔及皮下移植瘤模型,比较2种模型的生物学特性.方法:采用细胞悬液注射法将人上皮性卵巢癌细胞A2780/DDP注射于裸鼠皮下或腹腔,建立人卵巢癌裸鼠移植瘤模型,观察模型动物肿瘤的生长规律及组织学特性,流式细胞术分析细胞周期分布,免疫组化检测促黄体激素释放激素受体(Luteinzing-hormon...
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| 关 键 词： | 上皮性卵巢癌 动物模型 裸鼠 促黄体激素释放激素 |
Comparative study of the biological characteristics of two human ovarian carcinoma models in nude mice |
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| PU Cai-xiu
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CHANG Shu-fang
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SUN Jiang-chuan
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LIU Hong-xia
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ZHU Yi
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CHEN Jia.Comparative study of the biological characteristics of two human ovarian carcinoma models in nude mice[J].Journal of Chongqing Medical University,2011,36(11):1343-1346. |
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| Authors: | PU Cai-xiu CHANG Shu-fang SUN Jiang-chuan LIU Hong-xia ZHU Yi CHEN Jia |
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| Institution: | PU Cai-xiu,CHANG Shu-fang,SUN Jiang-chuan,LIU Hong-xia,ZHU Yi,CHEN Jia(Department of Obstetrics and Gynecology,the Second Affiliated Hospital,Chongqing Medical University) |
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| Abstract: | Objective:To establish intraperitoneal(IP) injection model and subcutaneous(SC) injection model of human ovarian carcinoma in nude mice and compare their biological characteristics.Methods:The cell suspension derived from A2780/DDP were injected intraperitoneally or subcutaneously in nude mice to establish human epithelial ovarian carcinoma models,and their growth behavior and biological characteristics were observed.Distribution of cell cycles were analyzed by flow cytometry(FCM).Expression of LHRH-R were ... |
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| Keywords: | epithelial ovarian carcinoma animal model nude mice luteinzing-hormone releasing hormone(LHRH) |
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