| 肾综合征出血热循环内皮细胞中黏着斑激酶及热休克蛋白70表达的研究 |
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| 引用本文： | 赵秀华,荆燕,王晓花. 肾综合征出血热循环内皮细胞中黏着斑激酶及热休克蛋白70表达的研究[J]. 中国自然医学杂志, 2011, 0(6) |
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| 作者姓名： | 赵秀华 荆燕 王晓花 |
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| 作者单位： | 济南市传染病医院; |
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| 基金项目： | 济南市卫生局立项课题(2008-29) |
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| 摘 要： | 目的通过检测肾综合征出血热(HFRS)患者循环内皮细胞(CEC)计数及CEC中磷酸化黏着斑激酶(FAKps910)、热休克蛋白70(HSP70)的阳性表达率,了解HFRS患者CEC计数及FAKps910、HSP70表达的动态变化,探讨其临床意义。方法 50例HFRS患者按病情分为轻型17例、中型20例、重型及危重型13例,健康对照组20例。流式细胞技术检测CEC计数及CEC中FAKps910、HSP70的表达情况。结果从发热早期至多尿期,HFRS患者CEC计数[发热早期:(13.37±5.19)个/μl;发热期末或低血压休克期:(47.73±19.89)个/μl;少尿期(41.11±16.21)个/μl;多尿期(19.29±4.81)个/μl]及HSP70的表达水平(发热早期:53.26%±10.54%;发热期末或低血压休克期:56.21%±8.83%;少尿期:40.13%±6.99%;多尿期:28.53%±6.79%)均显著高于对照组[CEC计数:(3.31±1.49)个/μl;HSP70:23.89%±4.70%],至恢复期[CEC计数:(3.86±1.98)个/μl;HSP70:26.52%±6.31%...
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| 关 键 词： | 肾综合征出血热 循环内皮细胞 黏着斑激酶 热休克蛋白70 |
Expression of focal adhesion kinase and HSP70 in circulating endothelial cells in hemorrhagic fever of renal syndrome |
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| ZHAO Xiu-hua,JING Yan,WANG Xiao-hua Jinan Infectious Disease Hospital,Jinan,Sh,ong ,China. Expression of focal adhesion kinase and HSP70 in circulating endothelial cells in hemorrhagic fever of renal syndrome[J]. Chinese Journal of Natural Medicine, 2011, 0(6) |
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| Authors: | ZHAO Xiu-hua JING Yan WANG Xiao-hua Jinan Infectious Disease Hospital Jinan Sh ong China |
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| Affiliation: | ZHAO Xiu-hua,JING Yan,WANG Xiao-hua Jinan Infectious Disease Hospital,Jinan,Shandong 250021,China |
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| Abstract: | Objective To investigate the clinical significance of circulating endothelial cells(CEC)and their expression of the phosphorylation state of serine 910 of focal adhesion kinase(FAKps910)and heat-shock protein 70(HSP70)in hemorrhagic fever of renal syndrome(HFRS) patients.Methods The study selected 20 healthy volunteers and 50 HFRS patients,the latter of which were with mild(17),moderate(20) and severe(13) conditions,respectively.CEC count and the expression of FAKps910 and HSP70 were determined by Flow Cyto... |
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| Keywords: | Hemorrhagic fever of renal syndrome Circulating endothelial cells Focal adhesion kinase Heat-shock protein70 |
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