垂体瘤手术对内分泌激素的影响

为了解垂体瘤手术对垂体激素分泌的影响，动态观察了１５０例垂体瘤患者在显微外科手术前后血清泌乳素（ＰＲＬ）、生长激素（ＧＨ）、甲状腺功能〔Ｔ３、Ｔ４、促甲状腺素（ＴＳＨ）〕、血皮质醇（Ｆ）和促肾上腺皮质激素（ＡＣＴＨ）的变化。结果：术后１周内ＰＲＬ、ＧＨ水平明显下降且与以后的ＰＲＬ、ＧＨ水平基本一致，故认为术后１周的ＰＲＬ、ＧＨ水平可做为判断手术疗效的主要指标之一；所有垂体瘤患者Ｔ３术后较术前均显著降低，提示手术摘除垂体腺瘤可引起Ｔ３水平的下降，而其他激素水平无明显变化。

The Effect of Adenomectomy on Endocrine Hormones

patients with pituitary adenoma (84 PRLsecreting pituitary adenomas, 30 GHsecreting pituitary adenomas and 36 nonfunctioning pituitary adenomas) were treated by adnomectomy. The dynamic studies of serum PRL, GH, Cortisol, ACTH and thyroidal functions (T3, T4, TSH) were performed before and after microsurgery. PRL and GH levels decreased strikingly within one week after treatment and didnt change afterwards. It was concluded that PRL and GH levels could be one of the major indicators to judge the effect of surgery. Serum T3 also decreased significantly and the other pituitary hormones had no significant changes. It suggested that adenomectomy could cause the serum T3 decreased.