舒肝颗粒对大鼠酒精性脂肪肝的疗效及其机制

目的探讨舒肝颗粒对酒精性脂肪肝的防治作用及其机制。方法用乙醇灌胃的方法制备酒精性脂肪肝大鼠模型。雌性Wistar大鼠随机分为乙醇组、舒肝颗粒干预组和正常对照组。乙醇组于实验12周末再分成2组。测定生化和病理指标。结果乙醇组ALT、AST第4周升高,舒肝颗粒组到第12周时才轻微增高。乙醇组丙二醛在12周升高,与正常组和舒肝颗粒组比较差异显著(P均<0.01)。12周末舒肝颗粒组与乙醇组超氧化物歧化酶活力比较差异显著(P<0.05)。12周末乙醇组肝组织脂肪变加重;舒肝颗粒组仅出现轻微脂肪变。治疗A组于实验16周末生化病理指标均正常,而治疗B组病理改变仍未恢复。结论舒肝颗粒具有良好的防治大鼠酒精性脂肪肝的作用,其作用机制可能与降低脂质过氧化、减轻坏死炎症反应有关。

Curative effect of Shugan granule on alcoholic fatty liver rats and its mechanism

Objective It is to discuss the preventive and therapeutic effect of Shugan granule on alcoholic fatty liver and its mechanism.Methods Alcoholic fatty liver rat models were prepared with ethanol lavage.Female Wistar rats were randomly divided into ethanol group,Shugan granule group and normal group.The ethanol group was divided into two subgroups at the 12th weekend.Then the biochemical and pathological indexes were detected.Results In ethanol group,the levels of ALT and AST rose at the 4th week,but those in Shugan granule group rose slightly at the 12th week.MDA in ethanol group rose at the 12th week,and it had significant difference compared with normal group and Shugan granule group(P<0.01).There was significant difference on the value of SOD between ethanol group and Shugan granule group(P<0.05).The adip-change of hepatic tissue in ethanol group was aggravation,which in Shugan granule group had little changed at the 12th week end.At the 16th week end,the biochemical and pathological indexes in group A became normal,but the pathological changes in group B did not recover.Conclusion Shugan granule has nicer preventive and therapeutic effect on alcoholic fatty liver rats.The mechanisms may be concerned with reducing lipid peroxidation and lightening necrosis and inflammatory reaction.