| 冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响 |
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| 引用本文： | 王锐,高普,刘剑刚. 冬连胶囊对实验性糖尿病大鼠早期胰岛素抵抗的影响[J]. 国际中医中药杂志, 2005, 31(1): 203-204. DOI: 10.3760/cma.j.issn.1673-4246.2009.03.003 |
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| 作者姓名： | 王锐 高普 刘剑刚 |
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| 作者单位： | 中国中医科学院西苑医院老年病科, 北京,100091;中国中医科学院西苑医院心血管实验室, 北京,100091; |
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| 摘 要： | Objective To investigate the effects of Donglian Capsule(the combination of Ophiopogonis Tuber Polysaccharide with Rhizoma Coptidis Alkaloids, OPRA for short, Component of Chinese medicine)on early insulin resistance in experimental diabetic rats. Methods The animal model of insulin resistance in 2 type diabetic was established by injecting low dose of STZ in 60 high fat-fed SD rats. After one week, the successful models were randomly divided into 4 groups: untreated, high and low OPRA-treated, mefformin-treated group, Meanwhile, a normal control group was designed. After four weeks, the differences of FBG, PG, INS and C-P were compared among the groups. Results The OPRA can significantly reduced the level of serum TC and FBG, increased the C-E ]Lightened the IRI(P<0.01). Conclusion The OPRA can reduce the level of serum TG and FBG, and decrease insulin resistance to protect the β-cell function.
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| 关 键 词： | 冬连胶囊 糖尿病胰岛素抵抗 胰高血糖素 |
Effect of the Donglian Capsule on Early Insulin Resistance in Experimental Diabetic Rats |
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| WANG Rui,GAO Pu,UU Jian-gang. Effect of the Donglian Capsule on Early Insulin Resistance in Experimental Diabetic Rats[J]. International Journal of Traditional Chinese Medicine, 2005, 31(1): 203-204. DOI: 10.3760/cma.j.issn.1673-4246.2009.03.003 |
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| Authors: | WANG Rui GAO Pu UU Jian-gang |
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| Abstract: | |
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| Keywords: | Donglian Capsule. Diabetic insulin ResistancePancreas Glucagon |
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