毛细支气管炎激素吸入治疗预防哮喘的研究

目的:观察毛细支气管炎患儿采用激素吸入治疗预防婴幼儿哮喘的疗效。方法:将毛细支气管炎患儿随机分为两组。观察组(54例)以丙酸氟替卡松吸入治疗,急性期每日2次,每次1揿(125μg),出院后每日早晨1次,每次1揿(125μg),连续半年;对照组(50例)未作激素吸入治疗,两组患儿出院后随访8~15个月。结果:观察组喘息发作14例(14/52),占26.92%,对照组22例(22/47),占46.80%,两组比较差异有显著性(P<0.05);观察组转为婴儿哮喘7例(7/52),占13.46%,对照组15例(15/47),占31.91%,两组比较差异有显著性(P<0.05)。结论:毛细支气管炎患儿给予激素吸入治疗,可显著减少喘息发作和降低婴幼儿哮喘的发生率,值得临床推广应用。

The theraputic effect of glucocorticoids inhalation on preventing infant asthma after bronchiolitis

Objective:To evaluate the theraputic effect of glucocorticoids inhalation on preventing infant asthma after bronchiolitis.Methods:104 infants were randomly divided into experimental group(54 cases,received fluticasone inhalation twice a day during infectious period,the dose of each time 125 μg,after out of clinical therapy period,it should be given for half a year,only once 125 μg every morning).The control group was received nothing.These cases were followed up for 8~15 months.Results:14 cases in experimental group(14/52,26.9%) and 22 cases in control group(22/47,46.8%) took place gasp.There was significant difference between the two groups(P<0.05).7 cases in experimental group (7/52,13.5%) and15 cases in control group(15/47,31.9%) developed into infant asthma.The differences between them were very significant(P<0.05).Conclusion:The glucocorticoids inhalation treating can significantly reduce gasp and asthma after bronchiolitis.So it deserves to be performed in more patients.