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| 心身1号片对胃溃疡大鼠胃黏膜保护修复作用的探讨研究 | |
| 引用本文： | 白丽君,贾锡莲,武成,刘志云.心身1号片对胃溃疡大鼠胃黏膜保护修复作用的探讨研究[J].天津中医药,2008,25(5):408-410. |
| 作者姓名： | 白丽君 贾锡莲 武成 刘志云 |
| 作者单位： | 1. 天津医科大学研究生,天津,300070 2. 天津医科大学总医院,天津,300052 3. 天津市中医药研究院附属医院,天津,300120 4. 天津市残疾人康复服务指导中心,天津,300381 |
| 基金项目： | 天津市卫生局中医中西医结合科研课题专项基金 |
| 摘 要： | 目的]研究心身1号片(XS-1)抗实验性大鼠胃溃疡的药理作用及机制.方法]用浸水-束缚应激法和醋酸烧灼法分别制作胃溃疡模型,观察心身1号片对胃溃疡的保护修复作用和对胃黏膜凋亡相关基因B细胞淋巴瘤/白血病基因-2(BcL-2)和BcL-2相关蛋白(Bax)表达的影响.结果]XS-1对大鼠水浸应激性胃溃疡的形成有显著预防的作用(P<0.01);对乙酸烧灼性溃疡有显著治疗作用(P<0.01).两组模型中,XS-1组Bcl-2阳性细胞数目较造模组增多,两者具有明显差异(P<0.01);造模组Bax阳性细胞数目较心身1号片组增多,两者具有明显差异(P<0.01).结论]中药XS-1能够促进溃疡大鼠胃黏膜组织Bcl-2的表达,降低Bax的表达,这可能是XS-1抗溃疡的作用机制之一. |
| 关 键 词： | 胃溃疡 凋亡 B细胞 淋巴瘤因子 X蛋白 心身1号片 |
| 收稿时间： | 4/3/2008 12:00:00 AM |
Study on protectve and reparing effect of "Xinshenyihao" in mucosa of rats with gastric ulcer |
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| BAI Li-jun,JIA Xi-lian,WU Cheng.Study on protectve and reparing effect of "Xinshenyihao" in mucosa of rats with gastric ulcer[J].Tianjin Journal of Traditional Chin Medicine,2008,25(5):408-410. | |
| Authors: | BAI Li-jun JIA Xi-lian WU Cheng |
| Institution: | BAI Li-jun1,JIA Xi-lian2,WU Cheng3,et al (1.Tianjin Medical University,Tianjin 300070,China,2. The General Hospital of Tianjin Medical University,Tianjin 300052,3. The Affiliated Hospital of Tianjin Academy of TCM,Tianjin 300120,China) |
| Abstract: | Objective] To study the pharmacological action and mechanism of Xinshenyihao(XS-1) in treating rats with experimental gastric ulcer. Methods] Gastric ulcer was induced in rats by using soaking and restraining stress and acetic acid damage to study the function of XS-1 in protecting and repairing gastric ulcer, and the effect of XS-1 on the expression of Bcl-2 and Bax in rats with gastric ulcer was also determined. Results] XS-1 played a significantly role in treating both acetic ulcer and in preventing s... |
| Keywords: | Gastric Ulcer Apoptosis Bcl-2 Bax Xinshenyihao |
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