糖调节受损合并良性前列腺增生症患者血清瘦素和胰岛素抵抗与前列腺体积的相关性研究

目的研究糖调节受损(IGR)合并良性前列腺增生症(BPH)患者血清瘦素(Lep)和胰岛素抵抗(IR)与前列腺体积(PV)的相关性。方法选取IGR且无BPH者100例,其中空腹血糖受损(IFG)组50例(IFG+non-BPH组),糖耐量异常(IGT)组50例(IGT+non-BPH组);IGR合并BPH者100例,其中IFG+BPH组50例,IGT+BPH组50例;健康对照组50例(NC组)。测量各组人群的身高、体重、腰围、臀围,测量空腹血糖、胰岛素、Lep、血脂、血清前列腺特异抗原(PSA),超声检测前列腺大小并计算体积,采用稳态模型评估法计算胰岛素抵抗指数(HOMA-IR)。探讨IGR合并BPH时Lep、IR及相关参数即体重指数(BMI)、腰臀比(WHR)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)与PV的相关性。结果 IGR组BMI、WHR、TG、LDL-C、FPG、Lep、HOMA-IR显著高于NC组(P<0.05)。IGT+BPH组Lep、HOMA-IR、TG、LDL-C水平高于IFG+BPH组(P<0.05)和IGT+non-BPH组(P<0.05)。多元线性回归分析显示PV与Lep、HOMA-IR、TG呈正相关,与HDL-C呈负相关。结论高血清Lep和IR共同参与了IGR合并BPH患者前列腺增生的发生和发展,糖脂代谢紊乱是PV增大的危险因素。

Correlation between prostatic volume and leptin/insulin resistance in patients with impaired glucose regulation and benign prostate hypertrophy

Objective To study the the correlation between the prostatic volume（PV） and leptin/insulin resistance in patients with impaired glucose regulation（IGR） and benign prostate hypertrophy（BPH）. Methods Clinical data were collected from fifty healthy controls（NC group）. One hundred patients of IGR without BPH, including fifty impaired fasting glucose（IFG＋non BPH group）, fifty impaired glucose tolerance（IGT＋no BPH group）. One hundred patients of IGR with BPH, including fifty IFG（IFG＋BPH group）, fifty IGT（IGT＋BPH group）. Fasting plasma glucose（FPG）, insulin, leptin, lipid profile and serum prostate specific antigen（PSA） were examined. The body mass index（BMI）, waistline-hip ratio（WHR）, PV, homeostasis model assessment of insulin resistance （HOMA-IR） were measured, and the correlation between PV and these parameters（BMI, WHR, TG, LDL-C and HDL-C） was assessed. Results In IGR group, the BMI, WHR, TG, LDL-C, FPG, leptin and HOMA-IR were statistically higher than NC group （P〈0.05）. The serum leptin, HOMA-IR, TG, LDL-C were higher in IGT＋BPH group than that without BPH group （P〈0.05） and IFG＋BPH group（P〈0.05）. The results showed that PV was positive correlated with leptin, HOMA-IR, TG and was negative correlated with HDL-C in IGR＋BPH group by multiple linear regression analysis. Conclusions High serum leptin and IR are involved in the disorder of glucose metabolism associated with the occurrence and development of prostatic hyperplasia in IGR with BPH patients. Glucose and lipids disorders were the risk factors of PV.