体外受精-胚胎移植中与生化妊娠相关因素的分析

目的分析体外受精-胚胎移植(IVF-ET)中导致生化妊娠的相关因素。方法回顾性分析2014年1月至2016年12月在我院行IVF/ICSI-ET助孕后生化妊娠的68个周期,以同期正常宫内妊娠的307个周期为对照组,比较两组患者的一般情况及助孕相关指标,采用Logistic回归分析筛选生化妊娠的影响因素。结果两组患者的一般情况及助孕相关指标均无显著性差异(P0.05)。多因素Logistic回归分析发现女方年龄、亚临床甲状腺功能减退(SCH)及受精方式是生化妊娠的影响因素(P0.05),且年龄偏大、合并SCH未治疗或治疗后仍不正常、ICSI操作的患者更易发生生化妊娠。结论开始IVF-ET治疗前应重视甲状腺功能检查,及时纠正SCH,严格掌握ICSI指征及规范操作,重视高龄女性患者,尽量改善其卵母细胞质量等有助于降低临床上生化妊娠发生率。

Analysis of influencing factors of biochemical pregnancy after IVF/ICSI

Objective:To analyze the influencing factors of the biochemical pregnancy after IVF/ICSI-ET.Methods:The data of 68 biochemical pregnancies and 307 intrauterine pregnancies in IVF/ICSI-ET cycles from January 2014 to December 2016 were retrospectively analyzed.The general conditions and the assisted pregnancy related indexes of the two groups were compared.The influencing factors of biochemical pregnancy were screened by univariate regression logistic analysis.Results:There was no significant difference in general conditions and the assisted pregnancy related indexes between the two groups (P＞0.05).Multivariate logistic regression analysis showed that female age,subclinical hypothyroidism (SCH) and fertilization method were the influencing factors of biochemical pregnancy (P＜0.05).The elder women with SCH who did not be treated or were still abnormal after treatment were more prone to biochemical pregnancy after ICSI treatment.Conclusions:The thyroid function tests should be paid attention to,SCI should be timely corrected before IVF/ICSI-ET,and ICSI indications should be strictly controlled.The elder patients need more attention to improve the quality of oocytes.All the measures will help reduce the incidence of biochemical pregnancy.