慢性脑血管功能不全患者血液流变学及脑血流动力学改变的临床研究

目的探讨慢性脑血管功能不全（CCVI）患者血液流变学及脑血流动力学改变的临床特点,为缺血性脑血管病防治提供依据。方法分别对60例CCVI患者和60例正常对照者行血流变学检查及脑血流动力学检查,并测量相关指标。结果 CCVI患者全血高切、低切及血浆黏度、纤维蛋白原、总胆固醇（TC）、甘油三脂（TG）均较正常对照者升高（P〈0.01或P〈0.05）,高密度脂蛋白胆固醇（HDL-C）较正常对照者降低（P〈0.01）;CCVI患者主要表现为血流速度异常（颅内血流异常率为80%）、颅内血管狭窄率为23.33%、搏动指数（PI）、阻力指数（RI）及收缩峰/舒张峰流速（S/D）值增高,而正常对照组颅内血流异常率为8.33%,颅内血管狭窄率为5%,CCVI组与正常对照组比较有显著差异（P〈0.01）。结论 CCVI患者存在血液流变学及脑血流动力学异常改变,这可能是CCVI患者早发现、早诊断、早治疗的新证据。

Changes of blood-rheology and cerebral blood flow dynamics in chronic cerebrovascular insufficiency patients

Objective To provide new evidences for the prevention and treatment of chronic cerebrovascular insufficiency through exploring the changed features of blood-rheology and cerebral blood flow dynamics in chronic cerebrovascular insufficiency patients.Methods 60 CCVI participants and health subjects were performed blood-rheology and cerebral blood flowdynamics test.Results The values of high and low shear blood viscosity,plasma viscosity,fibrinogen,total cholesterol,triglyceride were higher in CCVI group than those in health control group(P<0.01,P<0.05),while the level of HDL-c was lower in former than that in the latter(P<0.01).In CCVI group,it indicated that 80% abnormal blood flow velocity,23.33% Intracranial vascular stenosis and increased PI,RI and S/D.However,only 8.33% abnormal blood flow velocity and 5% intracranial vascular stenosis were observed in health control group.Conclusion The changed blood-rheology and cerebral blood flow dynamics could be found in chronic cerebrovascular insufficiency patients,which would be new evidences for early diagnosis,early detection and early treatment of chronic cerebrovascular insufficiency patients.