阿奇霉素治疗下呼吸道感染两种方案药物经济学评价

目的探讨阿奇霉素治疗下呼吸道感染的两种不同给药方案的疗效与经济效果。方法 88例下呼吸道感染患者,按入院先后随机分为观察组与对照组（每组44例）,观察组给予阿奇霉素静脉滴注,对照组给予阿奇霉素静脉-口服序贯治疗。观察两组疗效、不良反应,并运用药物经济学方法进行分析。结果两组有效率分别为87.6%和89.2%（P〉0.05）;成本-效果分析：C分别为415.0和260.1;E分别是87.6%和89.2%;C/E分别为4.74和2.91。结论两种不同的阿奇霉素给药方案治疗下呼吸道感染的临床效果相当,而从药物经济学的观点分析阿奇霉素静脉-口服序贯治疗为更经济的方案。

Pharmacoeconomic evaluation of two azithromycin therapeutic schemes for lower respiratory tract infection

Objective To explore the economic analysis and drug efficacy of two regimens of azithromycin in treatment of lower respiratory tract infection.Methods By order of admission,88 patients with lower respiratory tract infection were randomly divided into observation group and control group(n=44 cases).The observation group received Intravenous azithromycin and sequential therapy,the control group received azithromycin intravenous-oral sequential therapy,observed in each group effects,adverse reactions,and methods of economics to analyze the use of drugs.Result The efficiency of the two groups were 87.6% and 89.2%(P>0.05).The cost-effectiveness analysis: C were 415.0 and 260.1;E were 87.6% and 89.2%;C/E is 4.74 and 2.91,respectively.Conclusion Two kinds of azithromycin administration in the treatment of lower respiratory tract infection is very effective,but from the viewpoint of pharmacoeconomics azithromycin intravenous -oral sequential therapy is more economical solution.