重度子痫前期胎儿脐动脉血流动力学变化与围产儿预后关系探讨

目的探讨重度子痫前期胎儿脐动脉血流动力学变化与围产儿预后关系。方法应用彩色多普勒超声显像技术检测重度子痫前期孕妇100例（观察组）、同期正常孕妇100例（对照组）的胎儿脐动脉（UA）收缩期峰值流速（S）和舒张末期流速（D）的比值（S／D）、搏动指数（PI）、阻力指数（RI）值的变化，同时观察胎儿宫内生长发育情况及追踪围产儿结局。结果观察组胎儿脐动脉血流动力学异常发生率明显高于对照组，差异有统计学意义（P〈0．005）。观察组围产儿结局不良发生率明显高于对照组，差异有统计学意义（P〈0．005）。在观察组中脐动脉血流动力学异常组围产儿不良结局发生率高于血流动力学正常组，差异有统计学意义（P＜0．05）。结论重度子痫前期因胎儿一胎盘循环障碍，脐动脉血流阻力增加，与围产儿不良预后有关。彩色超声多普勒检测重度子痈前期患者胎儿脐动脉血流动力学变化，对预测胎儿宫内状况及围产儿预后有重要的临床价值。

Relationship between severe preeclampsia hemodynamics of fetal umbilical artery and perinatal prognosis

Objective To probe the relationship between severe preeclampsia hemodynamics of fetal umbilical artery and perinatal prognosis.Methods Color Doppler flow imaging was applied to detect the systolic and diastolic velocity ratios(S/D),pulsatility indices(PI) and resistance indices(RI) of umbilical artery of 100 severe preeclampsia pregnant women(observed group) and 100 normal pregnant women(control group) in same period.At the same time,the intrauterine growth of the fetus were observed and the perinatal outcomes were followed up.Results The rate of fetal umbilical artery hemodynamic abnormalities and the rate of adverse perinatal outcome of observed group was significantly higher than that of control group(P<0.005).Among the observed group,the rate of adverse perinatal outcome of abnormal fetal umbilical artery hemodynamic group was significantly higher than that of normal group(P<0.05).Conclusion Due to disturbance of placenta-fetal circulation,the blood flow resistance of fetal umbilical artery among the severe preeclampsia women was increased,so it was correlated with adverse perinatal grognosis.It was some clinic value to predict perinatal prognosis that umbilical artery hemodynamic change among severe preeclampsia women detected by Color Doppler.