Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat |
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| Authors: | V S Westerberg J D Geiger |
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| Affiliation: | Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg. |
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| Abstract: | We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesser degree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress. |
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