| 苯酰甲硝唑生物粘附微球的制备及粘附性能研究 |
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| 引用本文： | 周汉明,陈云舟,夏晶.苯酰甲硝唑生物粘附微球的制备及粘附性能研究[J].中国药师,2008,11(8). |
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| 作者姓名： | 周汉明 陈云舟 夏晶 |
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| 作者单位： | 1. 武汉市第三医院药剂科,武汉,430060
2. 华中科技大学同济医学院附属同济医院药学部 |
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| 摘 要： | 目的：筛选苯酰甲硝唑生物粘附微球的最佳处方并进行粘附性能评价。方法：应用正交试验设计，以收率和包封产率为指标，选择最佳处方配比；并以滞留率为指标考察制备微球的粘附性能。结果：当苯酰甲硝唑投药量为35％，分散相与连续相比为0．9，乳化剂Span-80用量为7．5g时，苯酰甲硝唑生物粘附微球的收率和包封产率最高；离体法与在体法测得微球胃粘膜上的滞留率分别为（93．4±4．5）％与（58．4±9．3）％。结论：该处方设计合理，制备工艺可靠，质量稳定。
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| 关 键 词： | 苯酰甲硝唑 生物粘附微球 正交设计 包封产率 粘附力 |
Study on the Preparation and Mucoadhesive Property of Benzoyl Metronidazole Bioadhesive Microspheres |
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| Zhou Hanming Chen Yunzhou Xia Jing.Study on the Preparation and Mucoadhesive Property of Benzoyl Metronidazole Bioadhesive Microspheres[J].China Pharmacist,2008,11(8). |
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| Authors: | Zhou Hanming Chen Yunzhou Xia Jing |
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| Institution: | Zhou Hanming~1 Chen Yunzhou~2 Xia Jing~1 (1.Department of Pharmacy,Wuhan Third Hospital,Wuhan 430060,China,2.Department of Pharmacy,Tongji Medical College,Huazhong University of Science , Technology) |
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| Abstract: | Objective:To choose the best formulation of benzoyl metronidazole bioadhesive microspheres and investigate its muco- adhesive property.Method:The optimum formulation was investigated by orthogonal design with the yield and entrapment efficiency and its mucoadhesive property was studied using stagnation percentage as the content index.Result:The yield and entrapment efficien- cy was best when the administration of benzoyl metronidazole was 35%,the phase ratio of disperse and continuous phase was 0.9 and the ... |
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| Keywords: | Benzoyl metronidazole Bioadhesive microspheres Orthogonal design Entrapment efficiency Adherence intensity |
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