Specificities of platelet autoantibodies in patients with lupus anticoagulants in primary antiphospholipid syndrome |
| |
Authors: | S Panzer M E Gschwandtner D Hütter S Spitzauer I Pabinger |
| |
Institution: | Clinical Department for Blood Group Serology, University of Vienna, W?hringer Gürtel 18–20, A-1090 Vienna, Austria, AT Internal Medicine I, University of Vienna, Austria, AT Department for Laboratory Medicine, University of Vienna, Austria, AT
|
| |
Abstract: | We have studied target platelet antigens in 22 patients with lupus anticoagulants and a primary antiphospholipid syndrome
in order to determine whether any specificities of platelet autoantibodies are correlated with thromboembolism, and if these
antibodies cross-reacte with phospholipids, which would suggest their role in the development of thromboembolic disease. Platelet
counts were median 203×109/l, range 100–298×109/l. Platelet antibodies were found in six thrombocytopenic patients and in further nine patients. All these 15 patients had
antibodies against GPIIb/IIIa, five patients against GPIb/IX, and six patients against GPIV. Anti-GPIb/IX and -GPIV occurred
only in combination with anti-GPIIb/IIIa antibodies. There was no correlation between the presence of detectable platelet
antibodies or any of their glycoprotein specificity and thrombocytopenia or the history of a thromboembolic disease. Eluates
from platelets contained only GPIIb/IIIa reactivities, but neither anti-GPIb/IX nor anti-GPIV. None of the eluates contained
lupus anticoagulant activity. In one case, the platelet eluates contained anti-GPIIb/IIIa and anticardiolipin IgG antibodies.
These results suggest that in patients with a primary antiphospholipid syndrome the presence of platelet autoantibodies neither
indicate a risk for thromboembolic disorder nor have lupus anticoagulant activity.
Received: 27 January 1997 / Accepted: 10 March 1997 |
| |
Keywords: | Lupus anticoagulants Platelet antibodies Antiphospholipid antibodies Thromboembolism Thrombocytopenia |
本文献已被 SpringerLink 等数据库收录! |
|